Early Lactate Clearance Rate is an Indicator of Outcome in Severe Sepsis and Septic Shock
نویسندگان
چکیده
منابع مشابه
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
OBJECTIVE Serial lactate concentrations can be used to examine disease severity in the intensive care unit. This study examines the clinical utility of the lactate clearance before intensive care unit admission (during the most proximal period of disease presentation) as an indicator of outcome in severe sepsis and septic shock. We hypothesize that a high lactate clearance in 6 hrs is associate...
متن کاملIs lactate clearance impaired in septic shock?
In a recent article in Critical Care, Tapia and colleagues evaluated the relationship between exogenous lactate clearance and liver perfusion in a short-term model of endotoxemic shock [1]. The authors concluded that the very low portal-hepatic vein lactate gradient was indicative of the inability of the liver to metabolize the increased lactate load. Although we believe that the authors addres...
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Morbidity and mortality from sepsis remains unacceptably high. Large variability in clinical practice, plus the increasing awareness that certain processes of care associated with improved critical care outcomes, has led to the development of clinical practice guidelines in a variety of areas related to infection and sepsis. The Surviving Sepsis Guidelines for Management of Severe Sepsis and Se...
متن کاملSevere sepsis and septic shock.
From the CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh (D.C.A.); and the Center for Experimental and Molecular Medicine, Division of Infectious Diseases, and Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterd...
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Among the different conditions of critical illness leading to admission to an Intensive Care Unit (ICU), sepsis remains the leading cause of death at the non-coronary medical ICU [1]. Even with optimal therapy, mortality rates of severe sepsis and septic shock are about 40 to 50% [2, 3]. Although there are numerous studies with varying methods from different countries, the incidence of severe s...
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ژورنال
عنوان ژورنال: BIRDEM Medical Journal
سال: 2018
ISSN: 2305-3720,2305-3712
DOI: 10.3329/birdem.v8i3.38127